PTSE 20/40 – Hot Melt Extrusion (HME), wet extrusion and granulation

Intended use

The Pharmaceutical Twin Screw Extruder PTSE 20/40 is used for development and production. Whether you are looking for Hot Melt Extrusion (HME), wet extrusion or granulation, the stand-alone extruder is well suited for pharmaceutical substances.

Pharmaceutical Twin Screw Extruder PTSE 20/40

  • Offers the same benefits as PTSE 12/36
  • Throughput up to 10 kg/h
  • High torque, high pressure
  • Process length can be shortened
  • Multiple feeding openings (top and side)


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Higher throughput and smart design for easy cleaning and handling

The GMP qualifiable Twin Screw Extruder allows a higher throughput and has more feeding openings than the PTSE 12/36. This offers you more configuration options for the set-up of your tests.

Smart designed, the extruder comes with a clamshell barrel, which can be opened horizontally, removable liners and segmented screws. These components can easily be reached, cleaned and dismounted and the process steps can be monitored visual-ly. Additionally, the surfaces of the machine are made of smooth steel.

As you can reach all components quickly, cleaning, dismounting and trouble shooting is facilitated.

  • Additives
  • Starch
  • Inorganic minerals
  • Pharmaceutical mixtures
  • Plasticizer
  • Solubility enhancement of poorly soluble APIs
  • Taste masking of poorly tasting APIs
  • Rapid method for production of films
  • Modify drug release properties – reduced risk of dose dumping
  • Wet extrusion
  • Wet granulation 
  • Conveyor belt (GMP qualifiable)
  • Pelletizer (GMP qualifiable)
  • Gravimetric und volumetric feeding systems (GMP qualifiable)
  • Liquid feeding systems (GMP qualifiable)
  • Containment systems (GEA) e.g. Buck System, Hicoflex – Charge Bag

Easy process control and data recording with the WinExt® Software including

  • Feeding rate
  • Temperature of the feeding zone
  • Temperature of the heating zones and of the die head
  • Screw speed
  • Product temperature
  • Pressure
  • Torque
  • Speed of the conveyor belt
  • Granulator speed
Diameter20 mm
Process length40 D
Max. temperature400º C
Max. pressure350 bar
Max. torque40 Nm/screw
Speed1200 rpm
Dimensions (L x B x H)1660 mm x 730 mm x 1197 mm
Throughput0,2 - 10 kg/h
Mains power3 x 400 V + N + PE, 50/60 Hz, 63A

Brochure Pharmaceutical Extrusion Solutions